Carl Sagan
Keeping an open mind is a virtue—but, as the space engineer James Oberg once said, not so open that your brains fall out.
At the heart of science is an essential balance between two seemingly contradictory attitudes–an openness to new ideas, no matter how bizarre or counterintuitive they may be, and the most ruthless skeptical scrutiny of all ideas, old and new. This is how deep truths are winnowed from deep nonsense.
If you wish to make apple pie from scratch, you must first create the universe.
They laughed at Columbus and they laughed at the Wright brothers. But they also laughed at Bozo the Clown.
Aka we don’t know what will happen until we have articulate a theory.